Cayenne is the international gateway into French Guiana. It is home to the airport and the main seaport, providing convenient access to the territory. Cayenne-Felix Eboue Airport is in the Matoury commune about eight miles from downtown. The airport is served by a number of airlines, including Air Caraibes, Air France, Surinam Airways, TRIP, and Air Guyane Express.

Air France offers regular flights to Paris and other international destinations, but there are no direct connections to the US so you will need to stop in Paris-Orly. Internal flights are also available to and from Maripasoula, Saint-Laurent du Maroni, Grand-Santi, and Saul via Air Guyane Express. Taxis pick up passengers right in front of the terminal, providing convenient transfers to any point in the city.